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Essay / Research Paper Abstract
A 5 page overview of the drug nitroglycerin and the role it plays in relieving the discomfort of angina. Details the cause of angina and the physiochemical action of the vasodilator nitroglycerin in abating it. Bibliography lists 4 sources.
Page Count:
5 pages (~225 words per page)
File: AM2_PPnitro.rtf
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Unformatted sample text from the term paper:
the most interesting synthetic substances ever manufactured. First synthesized in 1846, its original use was limited to that of a high explosive (Coburn, Ownes, and Willeitner, 2001). Subsequent
to its initial discovery, however, it was determined that it was also an effective drug. In 1879, after researchers noticed that even a small quantity of the oily
substance caused a severe headache when placed on the tongue, they eventually reached the conclusion that it was also useful in relieving angina (Coburn, Ownes, and Willeitner, 2001). Today,
the drug is one of the most commonly diagnosed to treat chronic angina (Barker, 2001). Nitroglycerin, a member of a class of drugs known as organic nitrates, is a
vasodilator (Coburn, Ownes, and Willeitner, 2001). The drug is dramatically effective in alleviating angina pectoris (Coburn, Ownes, and Willeitner, 2001).
Unlike some of the other more effective drugs discovered during the nineteenth century such as aspirin, digitalis, quinine and morphine, nitroglycerin is not a plant derivative (Barker, 2001). Indeed,
it is not found in nature at all. This is not really that surprising though when one realizes the explosive potential of the substance (Barker, 2001). In
its medicinal application nitroglycerin has been combined with an inert binder to stabilize it and remove its explosive potential (Barker, 2001).
As has been noted above, nitroglycerin is medicinally useful in the treatment of angina, a condition in which the arteries become blocked by plaque and the bloodflow is consequently interrupted
to some degree as is the amount of oxygen being delivered to the heart muscle. With angina attacks the individual experiences a degree of discomfort which is most often
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