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This is a 3 page paper that provides an overview of the achievements of Dr. Virginia Zakian. Emphasis is placed upon her research with yeast Pif1p and its function in inhibiting telomerase. Bibliography lists 5 sources.
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3 pages (~225 words per page)
File: KW60_KFsci066.doc
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structures, and in particular the protein structures known as telomeres. Telomeres are specialized structures at the end of DNA strands that exist for the purpose of acting as a buffer
that prevents actual DNA information from being distorted or deleted during the transcription and replication process; because the distortion of chromosomal information is implicated in a number of significant diseases
including cancer, it is vital to the health of an individuals that telomeres fulfill their roles properly. Without telomeres, the replication process results in the degradation of actual information encoded
in the DNA strand, and the resulting new cells are missing vital information that renders them incapable of accurately performing the bodily functions for which they were intended; telomeres, then,
are an essential component in maintaining the long-term stability of an organism at the cellular level (Princeton University, 2012b). The importance, then, of Zakians major research breakthrough is obvious; in
2005, her research team discovered that a simple form of yeast, Pif1p, acted as a regulatory agent upon telomerase, a protein agent that is responsible for adding new lengths of
telomeres to the ends of existing DNA strands (Boule, Vega, & Zakian, 2005). Typically, telomerase exists only in certain structures such as fetal cells, because the degradation of telomeres is
an intentional biological process; the means by which cells grow old and eventually die (Zakian, 2012). There are, however, certain instances, such as in the case of tumor cells, where
telomerase is present and continues adding telomeres, allowing cells to grow and divide well beyond what is desirable for the health of the human organism (Boule, Vega, & Zakian, 2005).
The fact that Pif1p is able to inhibit the activity of telomerase in adding new telomeres is quite significant, then, for researchers looking for a way to regulate and inhibit
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