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Essay / Research Paper Abstract
This 4 page paper answers a series of questions about colon cancer including what gene causes it, its symptoms, diagnosis and treatment. Bibliography lists 5 sources.
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4 pages (~225 words per page)
File: KV32_HVclncan.rtf
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Unformatted sample text from the term paper:
but it appears that the risk is greater for those whose relatives have the disease. People who are at risk for colon cancer need to work with their doctor to
decide how often and what type of screening they need. What gene mutates in colon cancer? In Lynch syndrome? In colon cancer, as in cancer generally, the disease is
caused by a mutation in the genes which then causes explosive cell growth. In this particular form of cancer, according to WebMD, the gene that mutates is TGFBR1 (Hitti). This
is a relatively new finding: the mutation "was found in about 10% to 20% of the 242 colorectal cancer patients the researchers studied, compared to 3% of 195 adults without
colorectal cancer" (Hitti). The sample is admittedly small, but the disparity between percentages is so great that researchers consider the finding significant (Hitti). In Lynch syndrome, which is "one of
the most prevalent inherited cancer syndromes, the mutation occurs in "inherited mutations in DNA mismatch repair genes (primarily MSH2, MLH1, MSH6, and PMS2)" (Green, et al). How do people
get colon cancer? People inherit the mutated gene from their parents. "FAP and HNPCC are both inherited in an autosomal dominant pattern. If a parent has FAP or HNPCC, his
or her children run a 50 percent risk of inheriting the mutated gene" ("Colon Cancer"). Inheriting a defective gene does not necessarily mean that a person will develop cancer, but
it greatly increases the predisposition toward developing the disease ("Colon Cancer"). Those who inherit "one bad copy of the APC gene are practically guaranteed to develop colon cancer by age
40," while those who inherit a bad copy of a "gene associated with HNPCC have an 80 percent chance" of developing the disease early in life ("Colon Cancer"). The odds
...