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Essay / Research Paper Abstract
An 8 page discussion of the various implications of antibiotic resistance. Mechanisms of antibiotic resistance are discussed. An emphasis is placed on Methicillin-resistant Staphylococcus aureus (MRSA), Extended Spectrum Beta-Lactamase (ESBL), and Vancomycin-resistant Enterococcus (VRE). Bibliography lists 7 sources.
Page Count:
8 pages (~225 words per page)
File: AM2_PPantib3.rtf
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Unformatted sample text from the term paper:
(1999) observes that in our attempts to sterilize our world we have instead created organisms with resistance to multiple antibiotics. Correlations have been reported by numerous researchers regarding increased
antibiotic resistance in microbial populations with high usage of antibiotic drugs (Henderson, 1999). Although antibiotics have, in fact, been used though centuries of folk medicine in indirect ways such
as the application of lichens to wounds, it has been only in the last one-hundred or so years of mankinds history that he started to make a concerted effort to
isolate and concentrate antibacterial substances which could be used therapeutically both in the treatment of his own diseases and in those of the plants and animals he found important.
Since the middle part of this century the pace has quickened substantially in the isolation and utilization of antibiotics. Antibiotic resistant strains of bacteria are of growing concern in
the country and the world in general. Of particular concern from a nursing perspective are Methicillin-resistant Staphylococcus aureus (MRSA), Extended Spectrum Beta-Lactamase (ESBL), and Vancomycin-resistant Enterococcus (VRE).
The concern which is now preoccupying the nursing profession in regard to antibiotic resistant bacteria is understandable given that MRSA is one of
the primary threats in terms of diseases encountered in ICUs in the US. Over fifty percent of S. aureus strains are found in ICUs, in fact (Rice, 2004).
The resistance expressed by this strain can be attributed to the expression of low-affinity penicillin-binding protein PBP2a.(Rice, 2004). This protein is encoded by "an acquired determinant on a transposable
element" (Rice, 2004). The strain is transmitted from person to person and thus requires stringent attention to disease control methodology in the nursing environment. This attention to disease
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