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Essay / Research Paper Abstract
A 4 page paper discussing nephrogenic diabetes insipidus (NDI), a rare kidney disorder in which the kidneys are unable to reabsorb much of the water that passes through them. NDI patients generally are continually thirsty and are in danger of dehydration, which is particularly dangerous for the very young and very old. Though NDI can be acquired, it generally is congenital and can be inherited in 3 forms: X-linked, autosomal recessive and autosomal dominant. Bibliography lists 6 sources.
Page Count:
4 pages (~225 words per page)
File: CC6_KSnephrDiabInsip.rtf
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Unformatted sample text from the term paper:
(NDI) is a rare kidney disorder in which the kidneys are unable to reabsorb much of the water that passes through them. Arginine vasopressin (AVP) is the antidiuretic hormone
responsible for signaling the kidney to concentrate urine, reabsorbing water for the bodys use. In NDI, the kidney is unable to respond to AVP. The result is that
the body voids large amounts of water in the form of highly dilute urine, rather than voiding much smaller amounts of water as concentrated urine. NDI patients generally are
continually thirsty and are in danger of dehydration, which is particularly dangerous for the very young and very old (Facts & Statistics, 2004). Though NDI can be acquired, it
generally is congenital. Genetic Base and Prevalence Though NDI can be acquired and "occurs more frequently than inherited NDI" (Facts & Statistics, 2004),
it is the inherited form that receives the greatest attention. Acquired NDI can be acquired at any stage in life through the use of some prescription drugs - notably
lithium derivatives - or as the result of a physical condition (Facts & Statistics, 2004). Genetic NDI, on the other hand, is one that shows greater promise of being
controlled in the future through the use of procedures such as gene therapy. At present, however, NDI can only be managed, not cured. Thibonnier (2004) states that the
"clinical phenotype of congenital nephrogenic diabetes insipidus has been linked to more than 155 loss-of-function putative mutations of the arginine vasopressin (AVP) V(2) receptor."
The Nephrogenic Diabetes Insipidus Foundation (NDIF) states that there are three types of congenital NDI. The most common (though in itself still extremely rare) is the X-linked form
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