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Karl Landsteiner: Outstanding Contribution To Medicine

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3 pages in length. The writer briefly discusses Landsteiner's discover of immunohistochemistry as it relates to blood typing. Bibliography lists 5 sources.

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3 pages (~225 words per page)

File: LM1_TLCLandstein.rtf

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from immunohistochemistry. He continued to investigate blood and how it related to antigens, antibodies and other immunological components, which ultimately led him down the road to tissue staining by way of immunohistochemistry. Indeed, this particular contribution to medicine was one of the most spectacular of his illustrious and lengthy career. The primary benefit of immunohistochemistry is its ability to allow scientists to view tissue and organ segments that would otherwise not be visible for research. In medicine, there is often the need to look at a single cell, such as when studying the brain. Comprised of billions of nerve cells, it may be necessary to view only one; in order to accomplish this, immunohistochemistry makes it possible to be able to do just that without having to disrupt the entire brain. It also makes it possible to grow a single cell outside of the body, as in tissue culture, which brings even more ease to the overall procedure. However, sometimes there is a "compromise between sensitive detection of the tracer and the immunohistochemical procedure" (Kressela, 1998, pp. 497-504) that precludes any beneficial findings. Landsteiner is responsible for developing the concept of immunohistochemistry as it is known today. The reason for choosing this Austrian immunologist and pathologist instrumental in discovering major blood groups was his ability to identify the ABO blood typing system that has brought blood transfusions to such a degree that they are considered quite routine in the medical world. Landsteiner, who studied medicine at the University of Vienna, discovered that blood was distinctly different among people, explaining that one type was not necessarily compatible with another while performing blood transfusions. The immunologists publication of The Specificity of Serological Reactions proved invaluable to ...

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