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Essay / Research Paper Abstract
This is a 15 page paper discussing five common chemotherapeutic agents in their treatment of cancer, their side effects and complications. Chemotherapeutic agents are used to interfere with the growth of cancer cells in an effort to destroy them. When studying the alkylating agents chlorambucil, thiotepa and carmustine and the antimetabolites fludarabine and floxuridine, it is has been found that although these chemotherapeutic agents are used in the treatment of various forms of cancer, they can also cause a great many side effects ranging from nausea, hair loss, bloody stools and urine, back and abdominal pain and even secondary cancer which may appear months or years after the administration of the treatment. Patients taking chemotherapeutic agents are also warned that they may cause birth defects during pregnancy or affect the children of mothers breast-feeding. Nevertheless, chemotherapeutic agents have been found to cure over 20 percent of new cancers diagnosed and with proper caution by the patient, physician and administering staff, the patient may overcome the cancer with this form of treatment.
Bibliography lists 12 sources.
Page Count:
15 pages (~225 words per page)
File: D0_TJChemo1.rtf
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Unformatted sample text from the term paper:
carmustine and the antimetabolites fludarabine and floxuridine, it is has been found that although these chemotherapeutic agents are used in the treatment of various forms of cancer, they can also
cause a great many side effects ranging from nausea, hair loss, bloody stools and urine, back and abdominal pain and even secondary cancer which may appear months or years after
the administration of the treatment. Patients taking chemotherapeutic agents are also warned that they may cause birth defects during pregnancy or affect the children of mothers breast-feeding. Nevertheless, chemotherapeutic agents
have been found to cure over 20 percent of new cancers diagnosed and with proper caution by the patient, physician and administering staff, the patient may overcome the cancer with
this form of treatment. Chemotherapy The understanding of chemotherapy and chemotherapeutic agents requires researchers to know the principles of tumor biology, cellular kinetics, pharmacology and drug resistance in order to
apply the appropriate treatment for patients suffering with cancer. Luckily, because of the development of chemotherapeutic agents, over 20 percent of new cancers can be cured by the application of
chemotherapy alone (Page, Principles, 2002). The study of cellular kinetics has shown that the normal cell cycle is composed of four phases
and chemotherapeutic agents are classified depending on which phase in the cell cycle they are active. Some chemotherapeutic agents are non-specific in their cell cycle, such as alkylating agents, are
the fraction of the cell kill depends on the dosage of the drug. Cell cycle specific agents however have a set number of cells which they can kill and an
increase in dosage will not increase the cell kill (Page, Principles, 2002). In the study of tumor kinetics has shown that tumors exhibit different growth depending on the proportion of
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