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Essay / Research Paper Abstract
5 pages in length. Considered relatively uncommon, the soft tissue neoplasm distinction of dermatofibrosarcoma protuberans (DFSP) is classified as having a malignancy grade of low to intermediate. Metastasis is not a prominent concern with this cancer inasmuch as it remains localized; however, a critical component of DFSP is its aggressive nature and high recurrence rate. Bibliography lists 6 sources.
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5 pages (~225 words per page)
File: LM1_TLCDermPro.rtf
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prominent concern with this cancer inasmuch as it remains localized; however, a critical component of DFSP is its aggressive nature and high recurrence rate (Chen, 2003). If the tumor
does metastasize, the prognosis is estimated at two years. A cutaneous cancer, DFSP appears in the skin and moves down into deeper tissue such as fat, muscle, bone and fascia.
Research has not definitively discovered the cellular cause of DFSP, however, findings suggest origin as neuroectodermal, histiocytic or fibrablastic in nature. Increased growth is noted when DFSP cells
are cultured with platelet-derived growth factor BB (PDGF-BB) (Chen, 2003). The incidence of DFSP found in the United States might be considered negligible when compared with other tumors, representing
0.1% of all cancerous growths, which translates to an approximate annual rate of 0.8 - 5 people per 1 million. Overall, racial partiality does not present itself with DFSP,
yet there is one particular aspect of the disease more predictable in black patients: uncommon pigmented variant called the Bednar tumor (Marcus et al, 1998). Both male and female
are afflicted nearly equally, with but a small lean toward men. Rutgers et al performed a study wherein fifty-seven percent of the total nine hundred and two patients were
men and the remaining forty-three percent were women (Chen, 2003). DFSP typically develops between the thirty-year span of ages twenty and fifty, having only seldom been associated with those
of extremely younger or older ages. Because of its slow growing manner, DFSP is not always recognized for the malignant tumor that it is; as it grows, however, it becomes
either a lumpy protuberance or sclerotic and/or atrophic plaque with a diameter of many centimeters (Chen, 2003), sometimes ulcerating as it grows in size. Both firm and irregular, the
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