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Essay / Research Paper Abstract
A 7 page description of cholesterol and its presumed role in heart disease. This paper describes cholesterol at a molecular level and reviews its biological function. Some of the conflicting data regarding cholesterol's role in heart disease is reviewed. Bibliography lists 6 sources.
Page Count:
7 pages (~225 words per page)
File: AM2_PPchole2.rtf
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Unformatted sample text from the term paper:
cholesterol molecule is a steroid core composed of four H atoms, one OH, one H3C and three CH3. Cholesterol is a lipid and is found in animal tissues.
Biologically cholesterol is most often associated with membrane structure. Its precise function then often depends on the fuction of a particular membrane. Cholesterol is also a primary component in
the steroids androgen and estrogen and cortisol, corticosterone, aldosterone, as well as other adrenal corticoid hormones which are a part of the stress mechanism. Bile production is also dependent
on cholesterol. Cholesterol enters the human body as a component of food. It is then trapped by special receptors that then pull
the cholesterol molecules into cells where it is then metabolized. Ren, Marques, Redford, Hylemon, Gil, Vlahcevic, Pandak (2003) report:
"Cholesterol metabolized to 7alpha-hydroxylated bile acids is a principle pathway of cholesterol degradation".
Cholesterol is believed to play a role in coronary artery disease, the leading cause of death in the U.S. High blood cholesterol has been believed to be a correlate
in heart disease for several decades. In a February 1990 "American Family Physician" article titled "Screening for High Blood Cholesterol" the Office of Disease Prevention and Health Promotion (National
Health Information Center) identified high blood cholesterol as one of the "principle modifiable risk factors for coronary artery disease". The article points out that "epidemiological, pathologic, animal, genetic and
metabolic studies" conducted for several decades previous to the articles publication support the so-called "lipid hypothesis": "the causal relationship
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