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This is a 3 page paper that provides an overview of Dr. Bonnie Bassler's accomplishments. The insights into bacterial quorum sensing are emphasized. Bibliography lists 2 sources.
Page Count:
3 pages (~225 words per page)
File: KW60_KFsci065.doc
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the field have yielded major insights that have not just redefined the fundamental principles by which it is understood that bacteria function, but also offers promise for practical application in
the development of new, more effective forms of antibiotics. The key breakthrough in Dr. Basslers work was the discovery of what she calls autoinducers; autoinducers are chemical molecules that bacteria
use to communicate with one another, typically to share basic facts about their population makeup. For instance, the bacteria vibrio fischeri is widely known to have the quality of bioluminescence,
but it was discovered that this bioluminescence only occurs whenever a population of vibrio fischeri bacteria reaches a certain density; moreover, when it does occur, the bioluminescence tends to follow
predictable circadian patterns (PSB, 2012). Another major type of marine bacteria, vibrio harveyi, adapt their level of virulence depending upon how dense their populations are via an autoinducer-driven process known
as quorum sensing; basically, the bacteria can sense when their population is strong enough to attack another organism and survive in the long-term and will not exhibit attacking behavior until
the autoinducers indicate that this population density has been reached (PBS, 2012). For a long time, Dr. Basslers work was overlooked, because while the behavior was interesting, it had only
been observed in marine bacteria that didnt pose much of a threat to (or have any interaction at all with) human organisms on a typical basis. This changed when it
was discovered that other types of bacteria such as serratia liquefaciens, a little understood bacteria that nevertheless manifests in often-fatal infections in humans, also exhibited quorum sensing behavior; serratia liquefaciens
enables the bacteria to know when its population is sufficient to conduct a virulent attack upon human tissue and develop a biofilm, making the strain more resistant to drug treatment.
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