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This 8 page paper provides an overview of research and implications of pharmacogenetics. Positive and negative aspects are discussed. Cost benefits are considered as well. Bibliography lists 8 sources.
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8 pages (~225 words per page)
File: RT13_SA211Rx.rtf
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activity (Meyer, 2000). Molecular genetics as well as genomics have transformed pharmacogenetics during the 1990s when it was discovered that the two alleles, carried by an individual at a given
gene locus, can be characterized at the DNA level, and their influence on the kinetics of either the receptor or drug function, can be measured by advanced analytical methods
(2000). This is true for metabolite detection or in regard to sophisticated clinical investigations (2000). Molecular studies in pharmacogenetics began with cloning and characterization of CYP2D6,[7,13] and this has been
extended to other human genes which includes codes for more than 20 drug-metabolizing enzymes (2000). II. What are Pharmacogenetics? The study of differences in genetic expression along
with protein production is called proteomics (Robbins-Roth 2000). Pharmacogenetics goes a step further and tries to isolate variations in gene sequences between individuals, in searching for gene mutations that
could be utilized to predict increased susceptibility to disease or related to a response to treatment (2000). The concept of Pharmacogenetics includes the determination process of the correct medicine
for an individual patient that is based on tiny genetic variances, something that is able to be measured by genetic testing of Single Nucleotide Polymorphisms (SNPs) ("Pharmacogenetics," 2002). An SNP
is a variation that presents in human DNA which occurs at a frequency of one for every 1,000 base pair (2002). Another way to define the concept is to think
of it as the application of genomes to pharmaceutical research, utilizing genome studies in order to identify genes which account for differences in people (2002). Based on genetic testing
for the predisposition to a disease or a variation in response to medications or therapies, pharmacogenetics has the potential to make healthcare more personal (2002). Pharmacogenetics tries to
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