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Essay / Research Paper Abstract
7 pages in length. The medical community has long been divided as to the role amyloid plaques play in the presence of Alzheimer's disease, with some stating without reservation that the "extracellular clumps of a protein fragment" (Beckman, 2004, p. 762) are the initial indicators of the disease, others argue they are the end result of other insidious events leading up to Alzheimer's. What both sides do agree upon, however, is that amyloid plaques are undeniably a tell-tale sign; it is the precise role they play that continues to baffle researchers. Bibliography lists 7 sources.
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7 pages (~225 words per page)
File: LM1_TLCAmyloid.rtf
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Unformatted sample text from the term paper:
of a protein fragment" (Beckman, 2004, p. 762) are the initial indicators of the disease, others argue they are the end result of other insidious events leading up to Alzheimers.
What both sides do agree upon, however, is that amyloid plaques are undeniably a tell-tale sign; it is the precise role they play that continues to baffle researchers because
the only way to definitively test the fiber-like deposits is postmortem. "Two hallmarks characterize Alzheimers disease: plaques and tangles. The plaques are chains of amino acids that are
pieces of the amyloid precursor protein, whereas the tangles are aggregates of the protein tau. It appears that the amyloid plaques are precursors to the formation of tangles; whether
or not this is the case, it is clear that these 2 abnormalities ultimately lead to loss of cognitive function" (Secko, 2005, p. 627). II. REVIEW OF LITERATURE The
presence of amyloid plaques no longer brings about a sense of uncertainty when it comes to the part it plays in progression of Alzheimers disease. Rather, the plaques have
been tagged as being an integral component in both the presence and development of this particular dementia that ultimately takes ones life. Research continues to uncover the previously unidentified
correlations between amyloid plaques and their role - cause or product of - in the presence of Alzheimers, with astrocytic involvement one of the most promising for the potential to
detect the disease early enough to mitigate the symptoms with existing medication. Establishing the determinants of amyloid plaques in relation to the presence
of A42-immunopositive material in brain astrocytes, one is compelled to investigate the myriad experiment data that has surfaced since it was first surmised that the two entities had any connection
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