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Essay / Research Paper Abstract
This is a 3 page paper which discusses how ionized drugs can be absorbed by the body.
The bibliography has 1 source.
Page Count:
3 pages (~225 words per page)
File: D0_JHAbso.rtf
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Unformatted sample text from the term paper:
of administration all contribute to determine how, when and why a drug is absorbed (Merck, 2005). Various drugs which mean the actual dosages of drugs - in tablets, solutions, or
capsules - are generally the combination of the actual drug plus other ingredients which assist the administration of the drug. These formulations help to make the determination as to
how the various drugs will be administered. A drug can be administered by mouth (orally), beneath the tongue, rectally, through injection either directly into a vein or into muscle
tissue, topically (placement directly on the skin or directly on the affected area) and/or by being inhaled. In order for a drug to be absorbed it needs to dissolve. Absorption
can only occur after the drugs, especially the solid drug forms such as tablets, disintegrate and enter a form of solution that can be absorbed (Merck, 2005). All methods of
administration with the exception of intravenously, requires that the drug must make its way through several semi permeable cell membranes on its route to the circulatory system (Merck, 2005).
The semi permeable cell membranes serve as barriers that inhibit selectively which drug molecules are allowed to pass into the circulatory system. These cell membranes are comprises of bimolecular lipid
matrix, which contains mostly cholesterol and phospholipids (Merck, 2005). The composition of lipids not only determine the permeability characteristics of the membrane, but also provides it with stability (Merck, 2005).
The bimolecular lipid matrix has various sizes and composition of protein embedded in it (Merck, 2005). These globular proteins are a part of the transportation and function as a
part of cellular regulation (Merck, 2005). There are several ways that a drug may pass through this biological barrier - by passive diffusion, facilitated passive diffusion, active transport, or
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